A Short Note On Diphtheria, An Organism That Frequently Cause Diphtheria
Corynebacterium diphtheria is an organism that frequently causes diphtheria in humans. Diphtheria was once known to be a great cause in the mortality of children, although the disease occurrence has since decreased tremendously due to the creation of the vaccine. There are still instances where the disease can occur. Corynebacterium diphtheriae is characterized by an aerobic, gram-positive bacilli that is non spore forming. It does not possess a capsule/is not encapsulated and is non motile. The optimal temperature of Corynebacterium diphtheriae is 37 degrees.
Corynebacterium diphtheriae is spread through droplet transmission. Although the cutaneous form of Corynebacterium diphtheriae is not as common, contact with the cutaneous infection may result in the disease. To a lesser extent, other ways of acquiring the bacteria include the use of fomites and also aerosols. Humans are the most notable reservoirs of the bacteria.
The major virulence factor that is used by Corynebacterium diphtheriae is the Diphtheria toxin. Although there is not much that is known about the other virulence factors, there is agreement that other factors exist and accompany the Diphtheria toxin. One that is suggested is the existence of a colonization factor (1). This allows it to be more successful compared to others in its nasopharyngeal niche, as findings show that lysotypes are existent for a significant course of time before change occurs (1). Recent findings have…